Botulinum neurotoxin type-A (BoNTA) is a zinc- dependent endopeptidase that specifically targets the neuromuscular junction. The active form of BoNTA is comprised of two subunits, the heavy chain and light chain, linked by a single disulfide bond. Endocytotic uptake of BoNTA causes a light chain conformational change which results in the proteolytic cleavage of the docking protein SNAP-25.3,9 Cleavage of SNAP-25 ultimately paralyzes the muscle by preventing the vesicular release of acetylcholine into the synaptic cleft.3, The resulting chemodenervation halts muscle growth and results in decreased fiber size and myonuclear number within 7 days.
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